• DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia 

      Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; Landfors, Mattias; Larsson, Pär; Kanerva, Jukka; Schmiegelow, Kjeld; Flægstad, Trond; Jónsson, Ólafur Gísli; Frost, Britt-Marie; Palle, Josefine; Forestier, Erik; Heyman, Mats; Hultdin, Magnus; Lönnerholm, Gudmar; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-05)
      <p><i>Background</i>: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL ...